Automated Drug Infusion System has plural pumping channels that operate independently for intravenously infusing drugs and fluid. The pumping channels are controlled by a microprocessor-based host controller that monitors each of the channels concurrently. It is suitable for identifying the particular drug that is to be pumped through a channel, preventing priming of a channel unless verification is provided that the channel is not connected to a patient and initiating the priming of each of the pumping channels independently.