Profile: Reference Diagnostics, Inc. specializes in offering diagnostic products. We provide these products to hospitals and clinical laboratories. hsCRP is intended for use in the determination of C-reactive protein (CRP) in human serum or plasma. Measurement of CRP is useful for the detection and evaluation of infection, tissue injury, inflammatory disorders & associated diseases. CRP is an acute phase reactant that rises dramatically in the case of inflammation or tissue destruction. Determination of CRP is clinically useful for detecting inflammation and infection, as well as for monitoring patient response to therapy & surgery. This test, based on latex immunoassay technology, is highly specific and accurately measures low levels of CRP. When CRP of the serum sample reacts with the latex microparticles sensitized with anti-CRP, an antigen-antibody reaction occurs, that results in the agglutination of the latex microparticles. The agglutination is detected by an absorbance change at 600 nm. The value of the absorbance change is proportional to the CRP concentration of the sample. The CRP concentration of the sample is determined by interpolation on the calibration curve obtained using standard samples of known CRP concentration.